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UNC-led team awarded $5.1M for cervical cancer prevention effort in Malawi
UNC Lineberger Comprehensive Cancer Center

The United States Agency for International Development and the U.S. National Academies of Science, Engineering, and Medicine are funding two new programs to prevent cervical cancer in sub-Saharan Africa, including a project led by UNC scientists and physicians in Malawi and one in Mozambique.

System-based intervention reduces racial disparities in treatment for early-stage lung cancer patients
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Sam Cykert, MD, and Geni Eng, DrPH, report that a combination of interventions reduced disparities in treatment and outcomes for black patients with early-stage lung cancer.

UNC, Ribisl among the highest ranked producers of scientific papers on e-cigarettes
UNC Lineberger Comprehensive Cancer Center

Researchers at the University of North Carolina at Chapel Hill published the third most number of scientific publications about electronic cigarettes between 2003-2018, according to a study published in the International Journal of Environmental Research and Public Health. The paper also cited UNC Lineberger's Kurt Ribisl, PhD, as one of the most prolific e-cigarette scientists.

Der to receive mentorship award from Carolina
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Channing Der, PhD, will be honored along with 23 other UNC faculty and teaching assistants at a banquet to celebrate the 2019 University Teaching Award winners.

Scientists uncover mechanism cells use to deactivate a signal that’s hyperactive in cancer
UNC Lineberger Comprehensive Cancer Center

In the journal Cell Reports, UNC Lineberger’s Michael Ben Major, PhD, and colleagues published a paper on how the WNT signaling pathway is regulated.

Researchers publish milestone review on the role of cell signaling proteins in cancer
UNC Lineberger Comprehensive Cancer Center

A review in Trends in Cancer led by UNC Lineberger's Antonio Amelio, PhD, explores the role of a group of cellular signaling integrators called cAMP-regulated transcriptional co-activators, or CRTCs, in cancer.

Stand Up To Cancer names UNC Lineberger researchers to ‘Dream Team’
UNC Lineberger Comprehensive Cancer Center

The multi-institutional team, which is co-led by UNC Lineberger's Gianpietro Dotti, MD, and includes six UNC Lineberger researchers, will focus on developing chimeric antigen receptor T-cell (CAR-T) therapies to recognize and attack T-cell lymphoma, a group of rare cancers of the blood and immune system.

Researchers identify driver of a key change in metastatic breast cancer
UNC Lineberger Comprehensive Cancer Center

In preliminary findings presented at the 2018 San Antonio Breast Cancer Symposium, researchers led by UNC Lineberger's Charles M. Perou, PhD, and Susana Garcia-Recio, PhD, reported they found increased expression of the gene FGFR4 in metastatic breast cancer tumors.

Franco explores the human genome in the hunt for novel cancer treatments
UNC Lineberger Comprehensive Cancer Center

Though he aspired for a career in marine biology, UNC Lineberger’s Hector L. Franco, PhD, discovered the field genetics at college, which led him to change his academic focus and earn a doctorate in biochemistry and molecular genetics.

Patient, doctor connect through rare cancer diagnosis
UNC Lineberger Comprehensive Cancer Center

In March of 2011, when she was 14 years old, Lily Newton was diagnosed with a rare cancer of the bone and soft tissue called Ewing sarcoma. Cancer changed Newton’s life in more ways than she could have imagined.

Art and science come together in N.C. Museum of Art exhibition
UNC Lineberger Comprehensive Cancer Center

“The Art of Science and Innovation," which features images by UNC Lineberger Comprehensive Cancer Center researchers, is on display through Monday, Jan. 14, at the North Carolina Museum of Art.

‘The singing patient’ hopes his music will inspire others
UNC Lineberger Comprehensive Cancer Center

Decorated military veteran MG Autry says service to others is central to his life. Even when he is facing his own health challenges, he would have it no other way.

Symposium held on geriatric oncology research, a field at the 'growing edge' of cancer therapy
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger leaders recently hosted the annual research symposium on geriatric oncology, which is the field of medicine that deals with diagnosis and treatment of cancer for adults 65 years and older.

UNC Lineberger in 2018: Strides made at the bench and bedside
UNC Lineberger Comprehensive Cancer Center

A look back at notable events and achievements at UNC Lineberger Comprehensive Cancer Center the past year.

Results 'encouraging' from phase II trial for relapsed acute myeloid leukemia
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Joshua Zeidner, MD, reported preliminary data at the 60th American Society of Hematology Annual Meeting from a phase II clinical trial for administering a high-dose of the chemotherapy treatment cytarabine followed by an immune checkpoint inhibitor, pembrolizumab, in patients with acute myeloid leukemia that had relapsed or no longer responded to other treatment.

Basch elected to American Society of Clinical Oncology Board of Directors
UNC Lineberger Comprehensive Cancer Center

As a member of the board, Ethan Basch, MD, MSc, FASCO, will help shape the direction and policies of the American Society of Clinical Oncology, the world's leading professional organization for physicians and oncology professionals caring for people with cancer.

Researchers identify experimental immunotherapy approach to target acute myeloid leukemia
UNC Lineberger Comprehensive Cancer Center

At the 60th American Society of Hematology Annual Meeting in San Diego on Dec. 3, Eben Lichtman, MD, presented preliminary findings from preclinical studies of CAR T-cells directed towards a potential target called B7-H3, which is found on the cell surface of certain types of AML.

Holiday party brings cancer center together, gives the boot to the Cancer Grinch
UNC Lineberger Comprehensive Cancer Center

Science met art at this year's holiday party as UNC Lineberger labs, departments and offices set out to win the Dr. Seuss-theme door decoration competition.

Grateful patient gives back to support ovarian cancer research
UNC Lineberger Comprehensive Cancer Center

Grateful for the care UNC Lineberger's Linda Van Le, MD, provided her, Cindy Carroll partnered with her friends and daughter Terri Yates to host Curated 4 Ovarian Cancer to raise funds for ovarian cancer research at UNC Lineberger. The evening featured a five-course dinner with wine pairing and a silent and live auction.

Study finds higher risk of breast cancer for women after childbirth
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Hazel Nichols, PhD, and collaborators from the Premenopausal Breast Cancer Collaborative Group identified elevated breast cancer risk after childbirth in women younger than 55.

**Inclement Weather Update**
UNC Lineberger Comprehensive Cancer Center

Cancer survivors honored at Carolina Breast Cancer Study celebrations
UNC Lineberger Comprehensive Cancer Center

The study’s leadership hosted events this fall in Concord, Greenville and Cary to recognize the contributions of the study’s participants and their caregivers as the study marked the 10th year of its third phase.

Wang and Serody awarded $2M grant to study personalized cancer vaccines
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Andrew Wang, MD, and Jonathan Serody, MD, and colleagues will investigate approaches utilizing nanotechnology to develop cancer vaccines that are personalized and enable the immune system to attack the specific mutations that are driving a person’s cancer.

Study shows promise for fighting relapsed blood cancer with CAR-T immunotherapy, chemotherapy
UNC Lineberger Comprehensive Cancer Center

At the 60th Annual American Society of Hematology Annual Meeting in San Diego on Monday, UNC Lineberger's Natalie Grover, MD, presented preliminary results from a clinical study of an investigational cellular immunotherapy for Hodgkin lymphoma and non-Hodgkin lymphoma expressing the CD30 protein marker.

NCI names Mayer interim director of cancer survivorship
UNC Lineberger Comprehensive Cancer Center

Deborah K. Mayer, PhD, RN, AOCN, FAAN, will serve as interim director of cancer suvivorship at the National Cancer Institute while maintaining her appointments and responsibilities at UNC, which includes overseeing a clinical practice working with breast cancer survivors.

Annual Thanksgiving lunch brings together patients, families and staff
UNC Lineberger Comprehensive Cancer Center

N.C. Cancer Hospital's 8th annual Thanksgiving Family Lunch offers a meal, community and a moment to reflect for 300 patients and caregivers.

Scientists train a computer to classify breast cancer tumors
UNC Lineberger Comprehensive Cancer Center

In a study published in the journal NPJ Breast Cancer, researchers reported they used a form of artificial intelligence called machine learning, or deep learning, to train a computer to identify certain features of breast cancer tumors from images.

Researchers identify resistance mechanism to possible pancreatic cancer treatment
UNC Lineberger Comprehensive Cancer Center

In the journal Cancer Cell, UNC Lineberger's Channing Der, PhD, and colleagues describe how pancreatic cancer may develop resistance to ERK inhibitors in pancreatic cancer.

Researchers awarded $5.5M to improve colorectal cancer screening in North Carolina
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Daniel S. Reuland, MD, MPH, and others involved in the Carolina Cancer Screening Initiative, received a grant from the National Cancer Institute to boost screening in North Carolina for the No. 2 leading cause of cancer death in the United States.

By solving a mystery of gene repair, scientists uncover an exception to biology’s rules
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Dale Ramsden, PhD, and his colleagues published a major study in the journal Science revealing surprising findings about the way major breaks in our DNA are repaired.

Der receives NCI Outstanding Investigator Award
UNC Lineberger Comprehensive Cancer Center

The National Cancer Institute’s Outstanding Investigator Award supports accomplished leaders in cancer research.

A cancer diagnosis changed their wedding plans, but strengthened their bond
UNC Lineberger Comprehensive Cancer Center

A diagnosis with a rare type of blood cancer called acute promyelocytic leukemia just days before his wedding influenced Dustin Riedesel's perspective on marriage, and inspired him and his now-wife, Katie, to raise money to support cancer research.

Mailed HPV tests can help find women at-risk for cervical cancer, study finds
UNC Lineberger Comprehensive Cancer Center

In the journal Obstetrics & Gynecology, researchers led by UNC Lineberger's Jennifer S. Smith published the results of mailing at-home, HPV self-collection kits to 193 low-income women in North Carolina who were overdue for screening according to national guidelines.

Federal Cancer Panel reports HPV vaccination rates remain too low to achieve full potential for cancer prevention
UNC Lineberger Comprehensive Cancer Center

The President’s Cancer Panel report raises concerns about the government’s Healthy People 2020 goal of 80 percent of age-eligible adolescents being vaccinated against HPV infection.

Oncology Excellence Award winners demonstrate a commitment to others
UNC Lineberger Comprehensive Cancer Center

The North Carolina Cancer Hospital's 2018 Oncology Excellence Awards highlight excellence in service to patients and colleagues.

Hingtgen awarded Hettleman Prize
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Shawn Hingtgen, PhD, is being honored with a Phillip and Ruth Hettleman Prize for Artistic and Scholarly Achievement by Young Faculty in recognition of his research that is focused on harnessing the potential of stem cells to develop new and better methods for treating terminal cancer.

UNC Lineberger director champions 'breadth and depth' of center's research
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger Director H. Shelton Earp, MD, highlighted the major cancer research, clinical care and fundraising milestones from the past year as part of his “State of the Cancer Center” update, which was delivered Oct. 16 at the center's annual scientific retreat.

Major gift, cancer survivors highlights of Blue Ribbon Gala
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's celebration of its donors, faculty and patients is capped off by a $10 million donation by Etteinne “ET” and W. G. Champion “Champ” Mitchell of New Bern, North Carolina, to support blood cancer research.

Former patient donates $10 million to further blood cancer research at UNC Lineberger
UNC Lineberger Comprehensive Cancer Center

Etteinne “ET” and W. G. Champion “Champ” Mitchell of New Bern, North Carolina, will create a new fund supporting ground-breaking research in blood cancer at UNC Lineberger Comprehensive Cancer Center, including lymphoma, leukemia and myeloma research, in gratitude for the care Champ received and to bolster research directed at finding cures.

UNC Medical Center Department of Pharmacy earns Innovator Award for reducing drug waste
UNC Lineberger Comprehensive Cancer Center

At it 35th Annual National Oncology Conference, the Association of Community Cancer Centers recognized the North Carolina Cancer Hospital, UNC Lineberger's clinical home, for early adoption of a program to reduce drug waste and reduce drug cost.

HPV blood test shows promise for tracking head and neck cancer after treatment
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Bhishamjit S. Chera, MD, will present preliminary findings at the 60th Annual Meeting of the American Society for Radiation Oncology on Tuesday from a study that evaluated a blood test for HPV-linked oropharyngeal squamous cell carcinoma, which is a cancer of the back of the throat. The findings demonstrated the test could be an effective and less costly alternative for monitoring for cancer recurrence after radiation treatment.

The Mary Kay Foundation awards UNC Lineberger $100,000 cancer research grant
UNC Lineberger Comprehensive Cancer Center

Gianpietro Dotti, MD, will use the $100,000 grant to conduct research into the use of cellular immunotherapy to treat solid tumors such as neuroblastoma, glioblastoma, ovarian cancer, pancreatic cancer and triple negative breast cancer.

Scientists zero in on ways to boost colorectal cancer screening
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Daniel Reuland, MD, MPH, and colleagues published in JAMA Internal Medicine a review of data from 73 randomized clinical trials that tested different ways of increasing screening for colorectal cancer. Their analysis identified three approaches as being the most effective.

Metastatic breast cancer patients report high level of financial impact
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Stephanie Wheeler, PhD, investigated the extent and severity of negative financial effects of cancer among women with breast cancer that has spread in the body. The preliminary results were presented at the American Society of Clinical Oncology’s Quality Care Symposium, held Sept. 28-29 in Phoenix.

Insights about prostate cancer resistance could lead to treatment strategies
UNC Lineberger Comprehensive Cancer Center

In the journal Molecular Cell, researchers led by UNC Lineberger's G. Greg Wang, PhD, and H. Shelton Earp, MD, describe the role of a protein variant called androgen receptor variant 7 (AR-V7), which is an alternative form of the androgen receptor that plays a key role in prostate cancer development and treatment.

Study focused on improving radiation treatment for cancers in pet dogs
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Paul A. Dayton, PhD, and his colleagues have been awarded a five-year, $3.2 million grant from the National Cancer Institute to investigate how to improve radiation treatment for pet dogs undergoing treatment for sarcoma.

Susan G. Komen awards UNC Lineberger $1.1M for breast cancer research
UNC Lineberger Comprehensive Cancer Center

Included in the new investments by Susan G. Komen was $400,000 for UNC Lineberger’s Lisa Carey, MD, the physician-in-chief of the N.C. Cancer Hospital, Richardson and Marilyn Jacobs Preyer Distinguished Professor in Breast Cancer Research, chief of the UNC School of Medicine Division of Hematology/Oncology, and a member of the Komen Scientific Advisory Board, for a study of HER2-positive breast cancer.

Retreat highlights postdoctoral fellows’ research
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's 43rd Annual Postdoc-Faculty Research Day was held Tuesday at the Carolina Club.

Fast Break raises funds, awareness for cancer research
UNC Lineberger Comprehensive Cancer Center

The 14th annual Roy Williams’ Fast Break for Cancer on Tuesday has raised $209,462 to date, and the total will increase after an online auction concludes on Oct. 12. The event has brought in more than $2.7 million since 2005.

Breaking the link between obesity, gastrointestinal cancers
UNC Lineberger Comprehensive Cancer Center

In an article in the journal Nature Reviews Gastroenterology & Hepatology, UNC Lineberger’s Stephen Hursting, PhD, MPH, and his colleagues reviewed findings from research looking at the biological links between obesity and cancers of the colon, rectum, pancreas, liver, esophagus, gallbladder and stomach, as well as published studies on how diet, exercise, weight loss surgery, and other weight-related interventions may help reverse this connection.

Black women more likely to report not taking breast cancer medication as prescribed
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger’s Stephanie Wheeler, PhD, found that black women were more likely than white women to report not taking endocrine therapy for breast cancer as prescribed, which could help explain why hormone-receptor positive breast cancer mortality is higher among black women.

UNC Lineberger creates fund to help patients affected by Hurricane Florence
UNC Lineberger Comprehensive Cancer Center

Donations being accepted to help North Carolina Cancer Hospital patients who are experiencing financial challenges related to Hurricane Florence.

NIH awards $11.6M grant to support study of retail tobacco policies across the U.S.
UNC Lineberger Comprehensive Cancer Center

Three innovative and complementary research projects, done in partnership with UNC at Chapel Hill, Stanford University and Washington University in St. Louis, will examine the role of the tobacco retail environment in promoting tobacco use and causing tobacco-related illnesses.

Prostate cancer care for older men estimated to cost Medicare $1.2B
UNC Lineberger Comprehensive Cancer Center

Researchers led by UNC Lineberger's Ronald C. Chen, MD, MPH, and Justin Trogdon, PhD, examined the costs associated with screening for prostate cancer, including treatment, for three years after diagnosis. They estimated that for men diagnosed in each of 2004, 2005, 2006, and 2007, the total cost for treating and screening for each group would be $1.2 billion for three years after diagnosis.

Findings could improve treatment for challenging acute leukemia in children
UNC Lineberger Comprehensive Cancer Center

There is no consensus on the best way to treat mixed phenotype acute leukemia, a rare blood cancer with survival rates of between 47 and 75 percent for children. Researchers from St. Jude Children’s Research Hospital and the University of North Carolina Lineberger Comprehensive Cancer Center have made important discoveries about the genetics of this disease that could lead to better treatment.

Hurricane Florence Update
UNC Lineberger Comprehensive Cancer Center

The N.C. Cancer Hospital, including its outpatient clinics and patient care services, currently is operating on a normal schedule. We are monitoring National Weather Service reports and will update this page as new information becomes available.

Johnson honored with Hyman L. Battle Distinguished Cancer Research Award
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger leaders held a reception Friday to honor Gary Johnson, PhD, the Kenan Distinguished Professor in the UNC School of Medicine Department of Pharmacology, and co-director of UNC Lineberger’s Molecular Therapeutics Program. During his 13-year tenure as chair, the Department if Pharmacology rose in national prominence and rankings. Johnson has been awarded the 2017-2018 Hyman L. Battle Distinguished Cancer Research Award.

Smith awarded $8.5M contract to compare treatments for recurrent bladder cancer
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Angela B. Smith, MD, MS, an associate professor in the UNC School of Medicine Department of Urology and director of urologic oncology, and her collaborators were awarded a contract from the Patient-Centered Outcomes Research Institute to compare bladder removal with medical therapy in bladder cancer patients.

Johnson honored with Hyman Battle Distinguished Cancer Research Award
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger leaders held a reception Friday to honor Gary Johnson, PhD, the Kenan Distinguished Professor in the UNC School of Medicine Department of Pharmacology, and co-director of UNC Lineberger’s Molecular Therapeutics Program. During his 13-year tenure as chair, the Department if Pharmacology rose in national prominence and rankings. Johnson has been awarded the 2017-2018 Hyman L. Distinguished Cancer Research Award.

Gallagher appointed as chief of breast surgery and surgical director of the UNC Breast Center
UNC Lineberger Comprehensive Cancer Center

Highly regarded in her field, Kristalyn Gallagher, DO, FACOS, brings both surgical and research experience to this leadership position.

Researchers lay the foundation for personalized immune treatments for leukemia
UNC Lineberger Comprehensive Cancer Center

In the journal Blood Advances, UNC Lineberger’s Ben Vincent, MD, Paul Armistead, MD, PhD, and their collaborators reported early findings from a new study that could aid in the development of immune-based treatments that are tailored to individual leukemia patients who are undergoing stem cell transplantation.

Stem cells show promise as drug delivery tool for childhood brain cancer
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Shawn Hingtgen, PhD, and his collaborators showed they could shrink tumors in laboratory models of medulloblastoma, and extend life. The study, published in PLOS ONE, is a necessary step toward developing clinical trials that would see if the approach works for children.

Doctor-patient discussions neglect potential harms of lung cancer screening, study finds
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Daniel Reuland, MD, MPH, report in JAMA Internal Medicine that their analysis of audio-recorded office visit discussions between doctors and patients found the quality of the conversation about lung cancer screening was “poor” and discussion of the potential harms of screening was “virtually nonexistent.”

Researchers find potential key to unlocking the immune system in pancreatic cancer
UNC Lineberger Comprehensive Cancer Center

In the journal Cancer Immunology Research, scientists led by UNC Lineberger's Yuliya Pylayeva-Gupta, PhD, revealed that a molecule called interleukin-35 plays a role in suppressing cancer-fighting immune cells in pancreatic cancer.

For 7-year-old boy, grandfather’s life is the best birthday gift
UNC Lineberger Comprehensive Cancer Center

Instead of presents, Bryson Mittman asked for donations to support UNC Lineberger's multiple myeloma research program and the Multiple Myeloma Research Foundation.

UNC Lineberger graduate students earn prestigious HHMI Gilliam Fellowships
UNC Lineberger Comprehensive Cancer Center

Megan Agajanian, in the lab of Ben Major, PhD, and Juanita Limas, in the lab of Jean Cook, PhD, will receive $50,000 each to support their biomedical research at UNC Lineberger and the UNC School of Medicine.

UNC Lineberger lymphoma conference draws experts from North Carolina and Virginia
UNC Lineberger Comprehensive Cancer Center

A range of specialties, including oncology, pathology, nursing and pharmacy, represented at meeting developed to promote discussions about lymphoma cases, share insights and plan ways to collaborate more effectively in regional, multicenter clinical trials.

Discovery of kidney cancer driver could lead to new treatment strategy
UNC Lineberger Comprehensive Cancer Center

In a study published in the journal Science, researchers led by UNC Lineberger's Qing Zhang, PhD, suggest that ZHX2 is a potential new therapeutic target for clear cell renal cell carcinoma, which is the most common type of kidney cancer.

By sending tests in the mail, researchers boost colorectal cancer screening
UNC Lineberger Comprehensive Cancer Center

Researchers with UNC Lineberger’s Carolina Cancer Screening Initiative, in collaboration with the Mecklenburg County Health Department in Charlotte, examined the impact of targeted outreach to more than 2,100 people insured by Medicaid who were not up-to-date with colorectal cancer screening.

Hyundai Hope On Wheels grant drives childhood cancer research
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger will use the $100,000 grant to support pediatric cancer research, including clinical trials, with the goal of developing better treatments and improving survival rates.

Researchers clarify role of mutations in glioblastoma
UNC Lineberger Comprehensive Cancer Center

In a preclinical study, researchers led by UNC Lineberger's Ryan Miller, MD, investigated whether the location of where the mutation occurred within the sequence of the PIK3CA gene affected the mutation’s ability to help drive cancerous growth. They also evaluated whether the location of the mutation would affect the cancer's response to certain treatments.

UNC Lineberger, King's College London scientists collaborate to accelerate cancer research
UNC Lineberger Comprehensive Cancer Center

Across two days in June, scientists held sessions on breast cancer and immunotherapy research, with a focus on identifying cooperative initiatives and funding opportunities.

UNC Lineberger hosts delegation from Malawi
UNC Lineberger Comprehensive Cancer Center

A team of Malawian health and government officials met with UNC health and university leaders, researchers and clinical staff across three days to prepare for the opening of the first dedicated cancer center in Malawi.

Luncheon celebrates oncology nursing fellows
UNC Lineberger Comprehensive Cancer Center

Nursing students Elizabeth Baldwin, Michael Lowry and Morgan Van Den Eynde were honored at the conclusion of the UNC Lineberger-Sylvia Lauterborn Oncology Nursing Fellowship.

Luncheon held to honor oncology nursing fellows
UNC Lineberger Comprehensive Cancer Center

An honorary luncheon was held on June 20, 2018 for nursing students Elizabeth Baldwin, Michael Lowry and Morgan Van Den Eynde at the conclusion of the UNC Linberger-Syvlia Lauterborn Oncology Nursing Fellowship.

Higher body fat linked to lower breast cancer risk in younger women
UNC Lineberger Comprehensive Cancer Center

An analysis co-led led by UNC Lineberger's Hazel B. Nichols, PhD, linked higher body mass index to lower breast cancer risk for younger women, even for women within a normal weight range.

Former NFL linebacker encourages cancer survivors to find joy in each day
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Cancer Survivors Day was held at The William and Ida Friday Center for Continuing Education in Chapel Hill on June 9. The day’s events included presentations and activities for survivors on exercise, clinical trials, and support programs for patients’ caregivers as well as lunch, art activities and dancing.

Former NLF linebacker encourages cancer survivors to find joy in each day
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Cancer Survivors Day was held at The William and Ida Friday Center for Continuing Education in Chapel Hill on June 9. The day’s events included presentations and activities for survivors on exercise, clinical trials, and support programs for patients’ caregivers as well as lunch, art activities and dancing.

Parents ranked cancer prevention as No. 1 provider reason for HPV vaccination
UNC Lineberger Comprehensive Cancer Center

A survey led by UNC Lineberger's Melissa Gilkey and collaborators found that parents ranked cancer prevention as the most compelling reason health care providers can give for recommending the human papillomavirus (HPV) vaccine.

Wedding bells ring at N.C. Cancer Hospital
UNC Lineberger Comprehensive Cancer Center

The care team on 4Oncology at the North Carolina Cancer Hospital went all out when Bernard McBryde asked if he could marry his fiancé while he was still receiving care as an inpatient.

Researchers map the genome of testicular cancer
UNC Lineberger Comprehensive Cancer Center

In a collaborative, multi-institution effort to map the genetic and genomic changes in cancer, researchers led by UNC Lineberger's Katherine Hoadley, PhD, analyzed 137 testicular germ cell tumors for potential mutations and other molecular changes. They identified molecular features of testicular germ cell cancers that could inform future efforts to improve treatment decisions, and help monitor patients to see if their cancer has come back. Their findings were published in Cell Reports.

Pagano Award recipients recognized
UNC Lineberger Comprehensive Cancer Center

Thomas Boothby, PhD, Hui Feng, PhD, and Jenna Honeycutt, PhD, were honored in a luncheon ceremony on Wednesday, June 6, in the Pagano Conference Room at UNC Lineberger.

UNC Lineberger among national leaders endorsing goal of eliminating HPV-related cancers in the US
UNC Lineberger Comprehensive Cancer Center

The directors of the 70 National Cancer Institute-designated cancer centers, including UNC Lineberger Comprehensive Cancer Center, say a national effort is needed to improve the rate of HPV vaccination and screening in the United States.

UNC Lineberger researchers share, learn about latest studies at ASCO Annual Meeting
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger faculty and trainees participated in more than 30 scientific or education sessions at the American Society of Clinical Oncology Annual Meeting in Chicago.

Blood mutations could contaminate genetic analyses of tumors
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers and colleagues led by Catherine C. Coombs, MD, reported research findings at the 2018 American Society of Clinical Oncology Annual Meeting that showed blood cell mutations accounted for as many as 8 percent of the mutations identified in large-scale genetic sequencing efforts at two major academic centers.

More frequent screening after prostate cancer treatment not linked to improved survival
UNC Lineberger Comprehensive Cancer Center

A study by UNC Lineberger's Ronald Chen, MD, MPH, and colleagues assessed whether monitoring prostate cancer patients following treatment with a PSA test every three months versus once a year would provide a long-term survival benefit.

Pagano Award recipients to be recognized
UNC Lineberger Comprehensive Cancer Center

Thomas Boothby, PhD, Hui Feng, PhD, and Jenna Honeycutt, PhD, will be honored in a luncheon ceremony on Wednesday, June 6, in the Pagano Conference Room at UNC Lineberger.

Melanoma survivors share stories of recovery amid treatment advances
UNC Lineberger Comprehensive Cancer Center

The seminar “Understanding Melanoma: From Prevention to Treatment" was hosted by the UNC Lineberger and the Melanoma Research Foundation on May 14 for patients and caregivers at the William and Ida Friday Center for Continuing Education in Chapel Hill. Physicians, researchers, patients and staff spoke about advances in treatment and care for melanoma, research and prevention, as well as best practices to address the psychosocial aspects of care.

By forming clots in tumors, immune cells aid lung cancer's spread
UNC Lineberger Comprehensive Cancer Center

Researchers led by UNC Lineberger's Chad Pecot, MD, report In the journal Nature Communications that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.

Commentary: Current evidence does not support call for more frequent colorectal cancer screening
UNC Lineberger Comprehensive Cancer Center

In an editorial published in JAMA, UNC Lineberger's Hanna Sanoff, MD, MPH, evaluated two studies that investigated whether higher-intensity testing for non-metastatic colorectal cancer is more effective.

Symposium showcases career options for scientists-in-training
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger hosted the Director’s Career Symposium to introduce scientists-in-training to a variety of career paths.

Bladder cancer model could pave the way for better drug efficacy studies
UNC Lineberger Comprehensive Cancer Center

In the journal Cancer Research, UNC Lineberger’s William Y. Kim, MD, Benjamin G. Vincent, MD, and colleagues report they have developed a mouse model of luminal bladder cancer, one of the two subtypes of advanced bladder cancer. The researchers said this model may help them to determine which patients may respond to immunotherapy treatments called checkpoint inhibitors.

Knowledge of e-cigarette health risk doesn't deter teen use, survey shows
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Seth Noar, PhD, and colleagues found that the majority of teenagers they surveyed knew about many of the health risks of e-cigarettes, but it had no influence on whether they had used e-cigarettes. However, they determined beliefs about addiction were a key discriminating factor among those who had and had not used e-cigarettes.

Knowledge of e-cigarettes health risk doesn't deter teen use, survey shows
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Seth Noar, PhD, and colleagues found that the majority of teenagers they surveyed knew about many of the health risks of e-cigarettes, but it had no influence on whether they had used e-cigarettes. However, they determined beliefs about addiction were a key discriminating factor among those who had and had not used e-cigarettes.

Roth, Johnson awarded $28 million for Illuminating Druggable Genome NIH grants
UNC Lineberger Comprehensive Cancer Center

The grants are part of the NIH program focused on experimental and informatics approaches to characterize understudied proteins from three gene families: ion channels, G protein-coupled receptors (GPCRs), and protein kinases.

Damania earns Faculty Award for Excellence in Doctoral Mentoring
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Blossom Damania, PhD, vice dean for research at the UNC School of Medicine, was honored with the award at the UNC-Chapel Hill doctoral hooding ceremony May 12.

Could reading our circadian clocks according to DNA repair optimize chemotherapy?
UNC Lineberger Comprehensive Cancer Center

For the first time, UNC Lineberger scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.

Viral protein helps drive cancer, study shows
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Blossom Damania, PhD, and Penny Anders, PhD, report in the Journal of Clinical Investigation how the viral protein vPK helps drive abnormal growth of immune cells called B cells. Their findings identify vPK as a potential druggable target to block or treat cancer in people infected with the virus.

Could Reading our Circadian Clocks According to DNA Repair Optimize Chemotherapy?
UNC Lineberger Comprehensive Cancer Center

For the first time, UNC Lineberger scientists led by Nobel laureate Aziz Sancar analyzed whole-genome DNA repair in an animal over 24 hours to find which genes were repaired, where exactly, and when, laying the groundwork for a more precise use of anti-cancer drugs.

UNC Lineberger co-hosts inaugural N.C. Adolescent and Young Adult Oncology Symposium
UNC Lineberger Comprehensive Cancer Center

Hosted by UNC Lineberger and the Mountain Area Health Education Center at the Carolina Inn, the inaugural symposium brought together multidisciplinary providers and researchers from around the state who are interested in improving care for adolescents and young adults with cancer.

Dotti awarded grant to launch early immunotherapy studies for ovarian cancer
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Gianpietro Dotti, MD, has received a grant for early laboratory studies into a method to attack ovarian cancer by genetically modifying a person’s own immune cells – specifically T-cells – to recognize ovarian cancer.

For mothers with advanced cancer, parenting concerns affect emotional well-being
UNC Lineberger Comprehensive Cancer Center

A new study led by UNC Lineberger's Eliza M. Park shows that parenting concerns can have a significant impact on the mental and emotional health of women with advanced cancer. In particular, they found that a mother’s emotional well-being was significantly linked with whether she had communicated with her children about her illness, and her concerns about how her illness will financially impact her children.

UNC Lineberger honors four with Pope Clinical Trainee Awards
UNC Lineberger Comprehensive Cancer Center

The 2018 Pope Clinical Trainee recipients were honored April 23 as part of a celebration for the John William Pope Foundation, which, in addition to endowing the Pope Clinical Trainee Awards through a gift made in 2014, made a new gift of $5 million to UNC Lineberger for the creation of the “Tomorrow’s Best Hope” Endowed Fellowship Fund.

UNC Lineberger Cancer Survivors Day to focus on education, shared experiences
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Griffith elected into National Academy of Sciences
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Jack Griffith, PhD, has conducted extensive research utilizing high-resolution electron microscopy to visualize protein-DNA interactions. He was elected into the National Academy of the Sciences, which is considered one of the highest scientific honors in the United States.

Breast cancer places greater financial burden on black women
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Stephanie Wheeler, PhD, and colleagues report in the Journal of Clinical Oncology that a survey of women who were diagnosed with breast cancer in North Carolina between 2008 and 2013 found that two years after a diagnosis, 58 percent of black women reported a negative financial impact of cancer, compared with 39 percent of white women.

UNC Lineberger honors four with Pope Clinical Fellows Awards
UNC Lineberger Comprehensive Cancer Center

The 2018 Pope Clinical Fellows were honored April 23 as part of a celebration for the John William Pope Foundation, which, in addition to endowing the Clinical Fellows Awards through a gift made in 2014, made a new gift of $5 million to UNC Lineberger for the creation of the “Tomorrow’s Best Hope” Endowed Fellowship Fund.

UNC Lineberger joins with Teen Cancer America, First Citizens Bank to announce plans for teen, young adult cancer program
UNC Lineberger Comprehensive Cancer Center

Gift from Teen Cancer America and First Citizens Bank will help UNC Lineberger to enhance its Adolescent and Young Adult cancer program, including expanding its research program focused on teens and young adults and developing plans for space tailored to this patient group.

UNC researchers identify promising delivery method for immunotherapy combination
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Andrew Z. Wang, associate professor in the UNC School of Medicine Department of Radiation Oncology, believe findings, published in the journal Advanced Materials, offer a promising new nanotechnology-based delivery method for an immunotherapy combination.

Scientists evaluate strategy to treat aggressive breast cancer once it's spread to the brain
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Carey Anders, MD, and Amanda Van Swearingen, PhD, senior research specialist at UNC Lineberger, presented preclinical findings at the American Association for Cancer Research Annual Meeting 2018 about a potential promising strategy for triple negative breast cancer brain metastases. They studied the PARP inhibitor, niraparib, in three models of triple negative breast cancer with alteration and loss-of-function changes in the BRCA1 gene.

UNC scientists create better laboratory tools to study cancer’s spread
UNC Lineberger Comprehensive Cancer Center

In the journal Nature Biomedical Engineering, UNC Lineberger’s Andrew Wang, MD, and colleagues report they have developed tissue-engineered models for cancer metastases that reflect the microenvironment around tumors that promotes their growth. They believe their models, which were developed to study colorectal cancer that had spread to the liver and lung, will help scientists studying why cancers tend to spread to certain organs rather than others.

Cigarillo packaging can influence product perception, study finds
UNC Lineberger Comprehensive Cancer Center

Researchers led by UNC Lineberger's Adam Goldstein, MD, and Clare Meernik, MPH, surveyed 2,664 young adults who were current users, never users, or past users of little cigars and cigarillos, finding cigarillo packs with colors and containing a flavor descriptor were rated more positively for taste and smell. Health warnings didn’t fully mitigate the draw of the packaging.

Carolina receives $10 million commitment from the Pope Foundation
UNC Lineberger Comprehensive Cancer Center

The donation will provide support for UNC Lineberger Comprehensive Cancer Center, UNC Horizons, the track and field program, and the Philosophy, Politics and Economics Program.

UNC Lineberger faculty present at leading national cancer research meeting
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger clinicians and scientists shared their research findings at the American Association for Cancer Research's annual meeting in Chicago, April 14-18. The meeting draws tens of thousands cancer experts from around the world to learn about the latest developments in cancer research.

For aggressive breast cancer in the brain, researchers clarify immune response
UNC Lineberger Comprehensive Cancer Center

In a preliminary study presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers led by UNC Lineberger's Benjamin Vincent, MD, and Carey Anders, MD, revealed findings for what kind of immune response the body is staging against triple negative breast cancer that has spread to the brain. They hope they can use these findings to improve patient responses to drugs that work by unleashing the immune system against cancer.

UNC Lineberger faculty present at AACR, leading national cancer research meeting
UNC Lineberger Comprehensive Cancer Center

Thousands of cancer researchers gathered in Chicago April 14-18.

Strategies identified to reverse obesity’s lingering, pro-cancer effects
UNC Lineberger Comprehensive Cancer Center

In preliminary findings presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers from the lab of UNC Lineberger's Stephen Hursting, PhD, reported on a number of studies examining possible ways to reverse obesity-linked biological changes.

UNC Lineberger researchers present at AACR Annual Meeting 2018
UNC Lineberger Comprehensive Cancer Center

Thousands of cancer researchers gathered in Chicago April 14-18.

To starve pancreatic tumors, researchers seek to block ‘self-eating,’ other fuel sources
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Channing Der, PhD, are reporting preclinical findings for a potential two-treatment strategy to block multiple mechanisms of cancer cell metabolism in pancreatic cancer at the American Association for Cancer Research Annual Meeting in Chicago. The findings will be presented from 8 a.m. to noon on Wednesday.

Lisa Carey, international breast cancer expert, appointed to Susan G. Komen’s Scientific Advisory Board
UNC Lineberger Comprehensive Cancer Center

As a member of Susan G. Komen's Scientific Advisory Board, UNC Lineberger's Lisa A. Carey, MD, will be responsible for helping guide Komen’s $956 million research program – second only to the U.S. government in funding of breast cancer research.

Payments to doctors linked to prescription practices for two cancer types
UNC Lineberger Comprehensive Cancer Center

Compared to physicians who didn’t receive any payments, those who received payments for meals and lodging from a drug manufacturer had higher odds of prescribing that company’s particular drug for certain cancer, reported Aaron Mitchell, MD, and colleagues in JAMA Internal Medicine.

Dayton inducted into American Institute for Medical Engineering College of Fellows
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Paul A. Dayton, PhD, was recognized for his contributions to biomedical engineering in the areas of contrast-enhanced ultrasound imaging and ultrasound-targeted therapeutics.

Carolina students create lasting bonds with pediatric patients
UNC Lineberger Comprehensive Cancer Center

UNC-Chapel Hill students volunteer at the N.C. Cancer Hospital, UNC Lineberger Comprehensive Cancer Center’s clinical home, to offer friendship and support to pediatric hematology and oncology patients and their families.

Genomic analysis of thousands of tumors supports new cancer classification
UNC Lineberger Comprehensive Cancer Center

A study by researchers from The Cancer Genome Atlas (TCGA) Network, and led by UNC Lineberger's Katherine Hoadley, PhD, supports an additional classification for human tumors.

UNC Lineberger researchers help map the cancer genome, generate key insights
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led two major projects to mark the finale of The Cancer Genome Atlas project, which was backed by the National Cancer Institute and National Human Genome Research Institute.

Classification for cancers revealed based on immune response
UNC Lineberger Comprehensive Cancer Center

In the journal Immunity, researchers co-led by UNC Lineberger's Benjamin Vincent, MD, reported their results of the analysis of immune responses in approximately 10,000 tumor samples. They revealed a new method for categorizing cancers based on their findings about the characteristics of the immune “microenvironment,” which they discovered using different types of genomic analysis, including RNA-sequencing.

Some e-cigarette ingredients are surprisingly more toxic than others
UNC Lineberger Comprehensive Cancer Center

Scientists led by UNC Lineberger's Robert Tarran, PhD, created a new screening technique to deduce the different toxicity levels of the more than 7,700 types of e-liquid flavors available to consumers.

UNC Lineberger symposium to focus on abnormal genetics, DNA repair in cancer
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s symposia have tracked advances in the understanding and treatment of cancer since 1977.

Improved capture of cancer cells could aid in disease tracking
UNC Lineberger Comprehensive Cancer Center

In the journal Clinical Cancer Research, UNC Lineberger's Andrew Wang, MD and colleagues reported that by forcing cancer cells to slow down and developing stronger molecular traps for them, they could identify large numbers of the cells in cancer patients undergoing radiation therapy.

Triangle Business Journal recognizes Martin with 2018 Women in Business Award
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Barbara Alvarez Martin, MPH, honored for her work to bring together public and business organizations to improve the health and well-being of Triangle-area communities and residents.

To halt breast cancer’s spread, scientists block amino acid found in asparagus
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers were part of a preclinical study led out of the Cancer Research UK Cambridge Institute that found that blocking the production of asparagine with a drug called L-asparaginase in mice with aggressive triple negative breast tumors, and putting them on a low-asparagine diet, reduced the breast tumor’s ability to spread.

UNC Lineberger researchers identify genetic ‘seeds’ of metastatic breast cancer
UNC Lineberger Comprehensive Cancer Center

In the Journal of Clinical Investigation, UNC Lineberger researchers published their analysis of the genetic differences they discovered in patients’ primary breast cancers and their metastatic cancers.

Prognostic tool could identify high-risk breast cancer patients
UNC Lineberger Comprehensive Cancer Center

In the journal Cell Chemical Biology, researchers led by UNC Lineberger's Xian Chen, PhD, report on potential prognostic tool that could be used to identify high-risk patients within particular subtypes of breast cancer.

Researchers identify molecular target for brain cancer, develop immunotherapy approach to attack it
UNC Lineberger Comprehensive Cancer Center

A team led by UNC Lineberger's Gianpietro Dotti, MD, has engineered immune cells to hunt glioblastoma, the most lethal primary brain tumor.

Mayer advising NCI on cancer survivorship issues and research
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Deborah K. Maher, PhD, RN, AOCN, FAAN, will continue to work at UNC-Chapel Hill while providing counsel to the National Cancer Institute’s Division of Cancer Control and Population Sciences on issues related to cancer survivorship.

Sellers named 2018 Health Care Hero
UNC Lineberger Comprehensive Cancer Center

Triangle Business Journal recognizes Jean Sellers, RN, MSN, for her work to improve access to high quality cancer care in North Carolina.

New therapeutic gel shows promise against cancerous tumors
UNC Lineberger Comprehensive Cancer Center

The lab of Zhen Gu, PhD, in the joint UNC-NC State biomedical engineering department developed a biodegradable hydrogel scaffold system to release chemotherapeutic and immunotherapeutic drugs at the tumor site.

Phase I clinical trial shows some promise for investigational drug for melanoma
UNC Lineberger Comprehensive Cancer Center

Three of 15 patients with BRAF-mutant melanoma had partial responses to an investigational compound in an early-stage study led by UNC Lineberger's Stergios Moschos, MD.

American Society of Clinical Oncology's annual report features UNC Lineberger research
UNC Lineberger Comprehensive Cancer Center

Research findings by Ethan Basch, MD MSc, and Ronald C. Chen, MD, MPH, were cited as being among the most impactful advances and policy developments in cancer in 2017.

Researchers define structure, function of enzyme key to blood cancers
UNC Lineberger Comprehensive Cancer Center

In the journal Nature, UNC Lineberger's Greg Wang, PhD, and colleagues reported findings about the structure and function of the DNMT3A enzyme complex, which helps control gene expression.

Patient research advocates help scientists-in-training communicate findings more effectively
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Patient Research Advocacy Group will help scientists and trainees to consider the patient perspective when conducting and presenting their research.

HIV exports viral protein in cellular packages
UNC Lineberger Comprehensive Cancer Center

A study from the lab of UNC Lineberger's Dirk Dittmer, PhD, found that HIV sends out a protein called Nef in cellular packages called exosomes.

Gene therapy researchers find viral barcode to cross the blood-brain barrier
UNC Lineberger Comprehensive Cancer Center

Scientists led by UNC Lineberger's Aravind Asokan, PhD, reveal how certain gene-carrying AAV vectors can penetrate the brain more efficiently to treat brain and spinal cord conditions, while reducing liver payload.

Milowsky to co-chair national bladder cancer task force
UNC Lineberger Comprehensive Cancer Center

Matthew Milowsky, MD, will help oversee a panel that provides insight on bladder cancer research and priorities proposed by the National Cancer Institute’s Genitourinary Cancers Steering Committee.

Milowsky to co-chair of national bladder cancer task force
UNC Lineberger Comprehensive Cancer Center

Matthew Milowsky, MD, will help oversee a panel that provides insight on bladder cancer research and priorities proposed by the National Cancer Institute’s Genitourinary Cancers Steering Committee.

UNC Lineberger researcher launches startup to improve radiation treatment in developing world
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Sha Chang was named to the latest class of KickStart Venture Services' Commercialization Award winners. She plans to use the funding to launch test site implementation of the startup's solution for improving radiation treatment precision for cancer.

Health indicators for newborns of breast cancer survivors may vary by cancer type
UNC Lineberger Comprehensive Cancer Center

In a study published in the International Journal of Cancer, researchers led by UNC Lineberger's Hazel Nichols, PhD, analyzed health indicators for children born to young breast cancer survivors in North Carolina.

Adolescents not susceptible to cigarette smoking are using e-cigarettes
UNC Lineberger Comprehensive Cancer Center

In a study led by UNC Lineberger's Adam Goldstein, MD, researchers found that efforts are needed to help youth remain nicotine free – especially those adolescents who aren’t otherwise susceptible to smoking cigarettes.

UNC Lineberger to use Colon Cancer Coalition grant to promote screening in Eastern North Carolina
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Carolina Cancer Screening Initiative is working in partnership with the Roanoke Chowan Community Health Center in Ahoskie, North Carolina, to to improve the colorectal cancer screening rates in a part of the state that has been significantly challenged by this disease.

Yeh and Strahl named Smithies Investigators
UNC Lineberger Comprehensive Cancer Center

The UNC School of Medicine selected professors from the departments of surgery, and biochemistry and biophysics for the annual award in honor of Oliver Smithies, UNC’s first Nobel Prize winner.

UNC Lineberger awards $1.1M in developmental research grants
UNC Lineberger Comprehensive Cancer Center

Eleven projects -- four basic science, four clinical/translational science and three population science -- were selected from a pool of 60 applicants from a broad range of disciplines.

'Corona Cares' brews up a record year of support for UNC Lineberger
UNC Lineberger Comprehensive Cancer Center

The program has contributed more than $1.24 million since its inception to UNC Lineberger’s Comprehensive Cancer Suppport Program.

Lineberger awards $1.1M in developmental research grants
UNC Lineberger Comprehensive Cancer Center

Eleven projects were selected from a pool of 60 applicants.

UNC Lineberger researchers honored for highly cited scientific publications
UNC Lineberger Comprehensive Cancer Center

Clarivate Analytics’ annual Highly Cited Researchers list included seven UNC Lineberger faculty members, whose scientific publications were among the top 1 percent most referenced from their field.

Cells lacking nuclei struggle to move in 3-D environments
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Keith Burridge, PhD, and published in the Journal of Cell Biology, examined the role of the physical structure of the nucleus in cell movement through different surfaces.

‘Corona Cares’ brews up a record year of support for UNC Lineberger
UNC Lineberger Comprehensive Cancer Center

The program has contributed more than $1.24 million since its inception to UNC Lineberger’s Comprehensive Cancer Suppport Program.

Narrowing the gap toward precision medicine for pancreatic cancer
UNC Lineberger Comprehensive Cancer Center

To improve treatment and our understanding of one of the deadliest cancers in the United States, UNC Lineberger's Jen Jen Yeh, MD, was involved in two studies that take different approaches to precision medicine for pancreatic cancer.

From a novel support group to a book, learning from seven widowed fathers
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Donald Rosenstein, MD, and Justin Yopp, PhD, have published a compelling book, “The Group: Seven Widowed Fathers Reimagine Life,” that recounts the lessons a group of widowed fathers learned in responding to loss and grief.

UNC Lineberger in 2017: A year of scientific and clinical advances
UNC Lineberger Comprehensive Cancer Center

University of North Carolina Lineberger Comprehensive Cancer Center faculty had an extremely productive 2017.

Cozzo wins 2017 Marci Kramish Campbell Dissertation Award
UNC Lineberger Comprehensive Cancer Center

Marci Campbell, PhD, was a national leader in cancer prevention and control, disparities and survivorship research, a faculty leader at UNC-Chapel Hill and a program leader at UNC Lineberger. The award established in her honor recognizes excellence in dissertation research focused on cancer and the population sciences.

UNC Lineberger researchers to develop comics, app to educate about childhood cancer in Malawi
UNC Lineberger Comprehensive Cancer Center

A grant from the Burkitt Lymphoma Fund for Africa will help UNC Lineberger researchers develop educational materials to improve communication between patients and providers – all with the goal of helping patients stay in care throughout their treatment.

Lineberger researchers to develop comics, app to educate about childhood cancer in Malawi
UNC Lineberger Comprehensive Cancer Center

A grant from the Burkitt Lymphoma Fund for Africa will help UNC Lineberger researchers develop educational materials to improve communication between patients and providers – all with the goal of helping patients stay in care throughout their treatment.

Cancer survivor brings joy to pediatric oncology patients
UNC Lineberger Comprehensive Cancer Center

For years, Eileen Sparks enjoyed making doll clothes for her granddaughter and family friends, and after her own battle with cancer, she found a new way to share her talent with some very deserving young patients at the N.C. Cancer Hospital.

To improve care for older adults with cancer, researchers share latest into biological age measures, assessments of care needs
UNC Lineberger Comprehensive Cancer Center

The latest efforts to measure biological, rather than chronological, age took center stage at UNC Lineberger's Geriatric Oncology Research Symposium.

Studies presented at SABCS seek to understand racial disparities for breast cancer
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger clinicians and researchers presented scientific findings at the 2017 San Antonio Breast Cancer Symposium, the world's largest breast cancer research meeting.

Gopal delivers winter commencement address
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Satish Gopal, MD, MPH, delivered UNC-Chapel Hill's Winter Commencement address.

Young cancer patient gets trip of a lifetime, joins SWAT team for the day
UNC Lineberger Comprehensive Cancer Center

Make-A-Wish of Eastern North Carolina and the Durham Police Department SWAT team helped reveal a once-in-a-lifetime surprise for Noah Marmito and his family at the N.C. Cancer Hospital on Thursday, Dec. 19.

UNC Lineberger researchers present blood cancer treatment advances at ASH
UNC Lineberger Comprehensive Cancer Center

The 59th American Society of Hematolology Annual Meeting, held Dec. 9-12, drew approximately 25,000 people from around the globe to Atlanta to hear the latest advances into the causes and treatment of blood cancers and disorders.

Chen awarded $11.9 million grant to study radiation treatments for prostate cancer
UNC Lineberger Comprehensive Cancer Center

Ronald C. Chen, MD, MPH, will use PCORI grant to conduct national comparative study of intensity-modulated radiation therapy and proton beam for prostate cancer.

Skin cancer treatment selfie goes viral, has public health lessons
UNC Lineberger Comprehensive Cancer Center

Researchers led by UNC Lineberger's Seth Noar, PhD, analyzed the impact of one viral social media post in generating awareness about skin cancer.

Study shows survival benefits for seeing an NCI specialist for multiple myeloma
UNC Lineberger Comprehensive Cancer Center

Preliminary findings presented at the 59th Annual American Society of Hematology Annual Meeting point to survival benefits for seeing a specialist for multiple myeloma in North Carolina.

Using software, researchers predict tumor markers that could be immune targets
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Benjamin Vincent, MD, reported preliminary findings at the 59th ASH Annual Meeting in Atlanta that are an early step in the overall plan to use the software’s predictions to develop immune-based therapies for leukemia.

Immunotherapy could be beneficial for relapsed acute myeloid leukemia
UNC Lineberger Comprehensive Cancer Center

Researchers led by UNC Lineberger's Joshua Zeidner, MD, presented preliminary results from an ongoing phase II trial of the checkpoint inhibitor pembrolizumab and chemotherapy for relaposed or refractory acute myeloid leukemia at the 59th American Society of Hematology Annual Meeting in Atlanta.

Biological factors don't completely explain racial disparities for ‘good prognosis’ breast cancer
UNC Lineberger Comprehensive Cancer Center

The biological features of patients’ tumors partially explained a racial disparity for women with hormone receptor-positive, HER2-negative breast cancer, but UNC Lineberger researchers led by Katherine Reeder-Hayes, MD, MBA, MSc, said it didn’t explain it completely. The preliminary findings were reported at the 2017 San Antonio Breast Cancer Symposium.

Forbes names Dees as a top breast cancer expert in the U.S.
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger’s Claire Dees, MD, is one of the country’s top 27 breast oncologists, according to Forbes magazine.

NCI grant to help more cancer patients become tobacco-free
UNC Lineberger Comprehensive Cancer Center

A grant from the National Cancer Institute will help expand tobacco cessation programs for cancer patients at the N.C. Cancer Hospital.

North Carolina wide receiver honored for devotion to patients
UNC Lineberger Comprehensive Cancer Center

University of North Carolina at Chapel Hill wide receiver lauded for his dedication to patients on the Bone Marrow Transplant Unit.

Leukemia & Lymphoma Society awards grant to Savoldo for immunotherapy research
UNC Lineberger Comprehensive Cancer Center

The Leukemia & Lymphoma Society grant will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."

The Leukemia & Lymphoma Society awards grant to Savoldo for immunotherapy research
UNC Lineberger Comprehensive Cancer Center

A grant from The Leukemia & Lymphoma Society will help fund clinical research led by UNC Lineberger's Barbara Savoldo, MD, PhD, into an investigational chimeric antigen receptor (CAR) T-cell treatment for acute lymphoblastic leukemia that would include a built-in "safety switch."

Damania named American Association for the Advancement of Science fellow
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Blossom Damania was one of three professors from UNC-Chapel Hill, and among 396 new fellows in total, who were recognized by their peers for their distinguished efforts to advance science and its applications.

Pairing cancer genomics with cognitive computing highlights potential therapeutic options
UNC Lineberger Comprehensive Cancer Center

Study findings suggest that cognitive computing could help physicians to stay abreast of an ever-expanding body of scientific literature as well as highlight potential cancer therapeutic options.

'Hats for Hope' founder gives back in memory of her daughter
UNC Lineberger Comprehensive Cancer Center

Elizabeth Stewart of Pender County and her supporters delivered more than 3,300 hats, blankets, socks, scarves and other items for cancer patients at the N.C. Cancer Hospital, UNC Lineberger's clinic home, on Thursday, Nov. 9, as part of Hats for Hope, the Annual Charli’ Ramsey Hat Drive.

Study: E-cigarette online vendors triple, concerns raised about marketing, pricing and delivery
UNC Lineberger Comprehensive Cancer Center

Two studies led by UNC Lineberger's Rebecca Williams, MHS, PhD, reveal trends in the marketing practices, pricing, delivery methods and other features of online e-cigarette vendors.

Cancer drug parity laws lower costs for many, but not everyone
UNC Lineberger Comprehensive Cancer Center

In an analysis of the impact of parity laws published in JAMA Oncology, UNC Lineberger researchers led by Stacie Dusetzina, PhD, and collaborators from Harvard Medical School report modest improvements in costs for many patients. However, patients who were already paying the most for their medications, saw their monthly costs go up.

Stover presented with inaugural Michael S. O'Malley Alumni Award
UNC Lineberger Comprehensive Cancer Center

The honor recognizes UNC Gillings School of Global Public Health graduates for outstanding population-based cancer research publications.

Stover presented with inaugural Michael S. O’Malley Alumni Award
UNC Lineberger Comprehensive Cancer Center

The honor recognizes UNC Gillings School of Global Public Health graduates for outstanding population-based cancer research publications.

Satish Gopal to deliver UNC-Chapel Hill Winter Commencement address
UNC Lineberger Comprehensive Cancer Center

Gopal, a member of UNC Lineberger, works to prevent, diagnose, and treat cancer in Malawi, Africa.

Dr. Satish Gopal, cancer program director for UNC Project-Malawi, to deliver UNC-Chapel Hill Winter Commencement address
UNC Lineberger Comprehensive Cancer Center

Gopal, a member of UNC Lineberger, works to prevent, diagnose, and treat cancer in Malawi, Africa.

Details uncovered in development of immune cell implicated in cancer, autoimmune diseases
UNC Lineberger Comprehensive Cancer Center

Scientists understand new details about the development of Th17, a type of immune cell that is believed to play a complex role in cancer, and is also implicated in autoimmune diseases.

Sexual function concerns not always reflected in prostate cancer treatment choices
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Ronald C. Chen, MD, MPH, found that preference for preserving sexual function was not strongly reflected in the treatment choices of men with low-risk prostate cancer.

Timing could matter to how responsive cancer cells are to treatment, study suggests
UNC Lineberger Comprehensive Cancer Center

In a new study published in Cell Systems, UNC Lineberger's Jeremy Purvis, PhD, and colleagues report that the timing of when DNA damage occurs within these different checkpoints matters to a cell’s fate.

Using new knowledge about cell division, researchers look to improve chemotherapy effects
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger member Michael J. Emanuele, PhD, was featured on the cover of The Journal of Biological Chemistry. The researchers uncovered new details about a protein called NUSAP1 during chromosome segregation, and offered a possible way to sensitize cancer cells to a particular type of chemotherapy.

Sharpless sworn in as National Cancer Institute director
UNC Lineberger Comprehensive Cancer Center

Norman E. Sharpless, MD, who served as director of the UNC Lineberger Comprehensive Cancer Center from January 2014-June 2017, was formally sworn in as director of the National Cancer Institute on Oct. 17.

Scientific retreat highlights faculty research, cancer center initiatives
UNC Lineberger Comprehensive Cancer Center

During the annual UNC Lineberger Scientific Retreat on Oct. 10, Interim Director Shelton "Shelley" Earp shared his assessment of current and future research initiatives. Eight center researchers gave presentations on their work, and a poster competition highlighted the work of graduate students and post-doctoral fellows.

Retreat features UNC Lineberger director's address, poster competition
UNC Lineberger Comprehensive Cancer Center

During the annual UNC Lineberger Scientific Retreat on Oct. 10, Interim Director Shelton "Shelley" Earp shared his assessment of current and future research initiatives. Eight center researchers gave presentations on their work, and a poster competition highlighted the work of graduate students and post-doctoral fellows.

Wheeler awarded UNC’s Hettleman Prize for Artistic and Scholarly Achievement
UNC Lineberger Comprehensive Cancer Center

University of North Carolina recognizes Stephanie Wheeler, PhD, for her research using mathematical modeling and systems thinking to address complex health services and policy questions.

UNC Lineberger postdoctoral fellows receive Pagano Award
UNC Lineberger Comprehensive Cancer Center

This year’s recipients of The Joseph S. Pagano Award are Rajarshi Choudhury, PhD, Rui Lu, PhD, and George Souroullas, PhD.

Scientists lay the foundation for better research into anti-RAS therapies
UNC Lineberger Comprehensive Cancer Center

In a paper published in the journal Science Signaling, Channing Der, PhD, and colleagues were able to screen chemical reagents to help researchers in the search for RAS-targeted therapies.

Honoring excellence in cancer care and services
UNC Lineberger Comprehensive Cancer Center

Friends, family members and colleagues recently gathered at the North Carolina Cancer Hospital to honor Paula Landman, RN, MSN, CPON, Tammy Triglianos, ANP, ANCOP, Glenda Blackwood and Craig Rifkin, RT, the 2017 Oncology Excellence Awards recipients.

Pagano honored for 42 years of leadership for UNC Lineberger’s postdoctoral trainees
UNC Lineberger Comprehensive Cancer Center

Joseph Pagano, MD, director emeritus of UNC Lineberger, has led UNC Lineberger's postdoctoral training program since its inception.

Delays for melanoma surgeries linked to insurance type
UNC Lineberger Comprehensive Cancer Center

Researchers report in JAMA Dermatology that surgical treatment delays – defined as surgery that occurred more than six weeks after diagnosis – were common. Medicaid patients were 36 percent more likely than private insurance patients to experience delays.

Blood test for HPV may help predict risk in cancer patients
UNC Lineberger Comprehensive Cancer Center

Preliminary findings from a study led by UNC Lineberger's Bhisham Chera, MD, and Gaorav Gupta, MD, PhD, suggest a genetic test for HPV16 in the blood could be useful to help assess risk for patients, and could help identify patients suitable for lower treatment doses. The findings were presented at this year’s American Society of Radiation Oncology Annual Meeting, held Sept. 24-27 in San Diego.

Roy Williams' Fast Break Against Cancer tops $2.4 million
UNC Lineberger Comprehensive Cancer Center

On Monday, North Carolina men's basketball coach Roy Williams hosted his 13th annual Fast Break Against Cancer breakfast and auction to support cancer research at the UNC Lineberger Comprehensive Cancer Center.

UNC Lineberger gears up for Victory Ride to Cure Cancer
UNC Lineberger Comprehensive Cancer Center

The V Foundation for Cancer Research hosted a launch party for its Victory Ride to Cure Cancer, a newly created charity cycling event that will take place in the Triangle next May and will benefit Duke Cancer Institute, UNC Lineberger Comprehensive Cancer Center, and the Wake Forest Baptist Health Comprehensive Cancer Center, as well as breakthrough cancer research nationwide.

Radiation oncology researchers present at ASTRO
UNC Lineberger Comprehensive Cancer Center

The American Society for Radiation Oncology’s 2017 Annual Meeting was held in San Diego Sept. 24-27.

To improve melanoma treatment, researchers look to block deletion of ‘self-reactive’ immune cells
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Maureen Su, MD, report on a potential new way to fight melanoma by blocking one of the immune system’s checks and balances.

Warnings of tobacco addiction considered believable
UNC Lineberger Comprehensive Cancer Center

In the journal Nicotine & Tobacco Research, UNC Lineberger researcher Adam Goldstein, MD, MPH, and Allison Lazard, PhD, compared how believable adults and adolescents found different warnings on addiction and tobacco.

Details of how cells 'release the brakes' on division revealed
UNC Lineberger Comprehensive Cancer Center

In a new study led by UNC Lineberger member Michael J. Emanuele, PhD, researchers discovered details of one way that cells release their brakes to allow replication and division to proceed.

Warnings of tobacco addiction considered 'very believable'
UNC Lineberger Comprehensive Cancer Center

In the journal Nicotine & Tobacco Research, UNC Lineberger researcher Adam Goldstein, MD, MPH, and Allison Lazard, PhD, compared how believable adults and adolescents found different warnings on addiction and tobacco.

Smitherman and Alexander join pediatric hematology-oncology program
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger Comprehensive Cancer Center is proud to announce that Andrew Smitherman, MD, MSc, and Thomas Alexander, MD, MPH, have been appointed to the Division of Pediatric Hematology-Oncology.

DeSimone named recipient of 22nd Heinz Award
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Joseph DeSimone, PhD, has been named the recipient of the 22nd Heinz Award in the Technology, the Economy and Employment category.

Research collaboration launched in South Africa to study Kaposi sarcoma
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Dirk Dittmer, PhD, has launched a collaboration with researchers in South Africa to investigate the biology of Kaposi sarcoma, a cancer caused by a herpes virus and associated with infection with HIV.

Savings less than expected for generic oral chemotherapy
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Stacie Dusetzina, PhD, compared the cost of the generic and brand-name version of capecitabine, which was one of the first high-priced chemotherapy pills to come off patent in the United States. Their findings offer a glimpse into what could be happening with generic competition in this specialty drug market.

Innovative cancer data resource expands, gains a new name
UNC Lineberger Comprehensive Cancer Center

Academics and policymakers are using the Cancer Information & Population Health Resource, or CIPHR, to knit together data from multiple public and private sources to examine a wide range of complex issues tied to improving cancer outcomes in North Carolina.

Zeny’s Garden offers patients peace of mind and body
UNC Lineberger Comprehensive Cancer Center

The newly established community garden at SECU Family House honors the legacy of the late Zeny Datiles, who was a dietician at UNC Lineberger, and provides a healthy respite -- and fresh vegetables -- for patients and their families.

Striving to save more children with cancer in Malawi
UNC Lineberger Comprehensive Cancer Center

Kate Westmoreland, MD, a fellow in the UUNC Department of Pediatric Hematology Oncology has a bold goal - increase the the survival rate of Burkitt lymphoma in Malawi from 30 percent to more than 60 percent. Learn how this Winston-Salem native is working to improve pediatric oncology in sub-Saharan Africa.

From the Ground up: The State of Cancer Care in Malawi
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Satish Gopal, MD, head of UNC’s cancer care efforts at UNC-Project Malawi, will welcome collaborators from across the region for the Malawi Cancer Care Symposium on Aug. 28 and 29.

Study sheds light on why some breast cancers have limited response to immunotherapy
UNC Lineberger Comprehensive Cancer Center

Jonathan Serody, MD, Benjamin Vincent, MD, and a team of UNC Lineberger investigators published findings in the Journal of Clinical Investigation that may explain why drugs designed to unleash the immune system against cancer were ineffective in treating a type of triple negative breast cancer. They determined “claudin-low” tumors were releasing a chemical signal to attract regulatory T-cells, which prevented the immune system from rejecting the cancer.

51 UNC Lineberger physicians recognized as 'Best Doctors'
UNC Lineberger Comprehensive Cancer Center

Best Doctors in America® List is the product of a national survey of physicians, who are asked which physicians they would see if they needed treatment for specific medical issues.

Gillings names Ribisl chair of health behavior department
UNC Lineberger Comprehensive Cancer Center

UNC Gillings School of Global Public Health has appointed UNC Lineberger's Kurt Ribisl, PhD, as chair of its health behavior department.

Researchers find genetic precursors of leukemia in cancer patients
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Catherine Coombs, MD, revealed new risk factors for “clonal hematopoiesis,” a medical phenomenon in which genetic mutations are found in the blood cells of patients who do not have an existing blood cancer.

Researchers find genetic precursors of leukemia in patients treated for non-blood cancers
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Catherine Coombs, MD, revealed new risk factors for “clonal hematopoiesis,” a medical phenomenon in which genetic mutations are found in the blood cells of patients who do not have an existing blood cancer.

Researchers look to improve detection of skin cancer lacking pigment melanin
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Nancy Thomas, MD, PhD, have identified key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin.

Rosenstein elected head of national psychosocial oncology society
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Donald Rosenstein, MD, director of the UNC Comprehensive Cancer Support Program, was elected to lead the American Psychosocial Oncology Society.

Aggressive breast cancers may contribute to racial survival disparities
UNC Lineberger Comprehensive Cancer Center

In the Journal of the National Cancer Institute, UNC Lineberger researchers led by Melissa Troester, PhD, published results of an analysis of approximately 1,000 invasive breast tumors. The study confirmed that young black women are more likely to have “triple negative,” or “basal-like,” breast cancers, a subtype that does not express any of the receptors for targeted biologic therapies. The study also identified variation by race within a clinical breast cancer type that has the greatest mortality disparity.

UNC Lineberger program focused on improving screening rates, reducing cancer deaths
UNC Lineberger Comprehensive Cancer Center

The Carolina Cancer Screening Initiative, led by Daniel S. Reuland, MD, MPH, brings together UNC Lineberger’s clinicians and public health researchers with community partners to implement evidence-based cancer screening programs to reduce cancer burden among North Carolinians.

Home test for HPV may be lifesaving for women who do not receive regular cervical cancer screenings
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger's Jennifer Smith, PhD, professor of epidemiology at the UNC Gillings School of Global Public Health, found that among a group of 429 women who did not undergo routine cervical cancer screenings, two-thirds used and returned an in-home self-test, and 15 percent test positive for human papillomavirus.

Clinical trials framework proposed to bring cancer treatments to sub-Saharan Africa
UNC Lineberger Comprehensive Cancer Center

In the journal PLOS Medicine, Satish Gopal, MD, MPH, cancer program director for UNC-Project Malawi, outlined a framework to design studies and bring cancer therapies to sub-Saharan Africa in the absence of clinical trial data specific to the region’s population and health care infrastructure.

Duke Endowment grant to help UNC Lineberger roll out lay patient navigation program across N.C.
UNC Lineberger Comprehensive Cancer Center

Thomas C. Shea, MD, associate director for Outreach Programs at UNC Cancer Network, and Jean Sellers, RN, MSN, clinical administrative director at UNC Cancer Network, will use the $600,000 grant to help implement the UNC Lay Patient Navigation Program in 10 hospitals and cancer care facilities that collectively cover a wide geographic region of the state.

Duke Endowment grant to help UNC Lineberger rollout lay patient navigation program across N.C.
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger to use $600,000 grant to help implement the UNC Lay Patient Navigation Program in 10 hospitals and cancer care facilities that collectively cover a wide geographic region of the state.

Clark, Freeman selected for 2017 Pope Clinical Fellows Awards
UNC Lineberger Comprehensive Cancer Center

Two fellows were honored with the 2017 Pope Clinical Fellows Awards for demonstrating excellence in cancer research and in clinical oncology practice.

UNC Lineberger-Sylvia Lauterborn Oncology Nursing Fellows honored with celebration
UNC Lineberger Comprehensive Cancer Center

Faculty and staff from UNC Lineberger and the UNC School of Nursing gathered together on Monday, June 26, to honor students Jackie Balliot, Madison Morgan and Kaitlyn Pickert upon completion of their oncology nursing fellowship program.

Using ‘sticky’ nanoparticles, researchers develop new strategy to boost body’s cancer defenses
UNC Lineberger Comprehensive Cancer Center

In the journal Nature Nanotechnology, UNC Lineberger researchers led by Andrew Wang, MD, report on strides made in the development of a strategy to improve the immune system's detection of cancer proteins by using “sticky” nanoparticles

Online program improves weight loss after child birth
UNC Lineberger Comprehensive Cancer Center

A study published in the Journal of the American Medical Association, and co-authored by UNC Lineberger member Deborah Tate, PhD, reported on the results of an Internet-based weight loss program in low-income women in the year after giving birth. By helping new mothers return to their pre-pregnancy weights, they hope to lower their risk for obesity and chronic diseases, such as cancer.

Muss named a ‘Giant of Cancer Care’
UNC Lineberger Comprehensive Cancer Center

Hyman B. Muss, MD, honored at a ceremony in Chicago for his contributions that have advanced the fields of supportive, palliative and geriatric cancer care.

Researchers strive to improve cancer care for older patients
UNC Lineberger Comprehensive Cancer Center

At the 2017 American Society of Clinical Oncology Annual Meeting in Chicago, UNC Lineberger researchers led by Hyman B. Muss, MD, presented preliminary findings from several studies focused on older adults with cancer.

UNC Cancer Survivors Day brings community together for day of celebration, education
UNC Lineberger Comprehensive Cancer Center

Cancer survivors, their care providers and UNC faculty and staff were at the William and Ida Friday Center for Continuing Education on Saturday, June 10, in a show of community and support, and to share information on issues facing survivors.

UNC Lineberger research featured at ASCO Annual Meeting
UNC Lineberger Comprehensive Cancer Center

Research presented by UNC Lineberger members was featured in plenary and other major sessions of the meeting this year, and was picked up by multiple media outlets.

Researchers show how a cancer gene protects genome organization
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger researchers has uncovered a crucial function of a yeast enzyme Set2, whose well-conserved human counterpart is often mutated in cancers, especially kidney cancer.

President Trump intends to appoint UNC Lineberger’s Norman Sharpless as National Cancer Institute director
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger Director Norman E. Sharpless, MD, is being considered as the next director of the nation's top cancer agency.

New models of kidney cancer may drive immunotherapy research
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger member William Y. Kim, MD, and his colleagues report in the journal Nature Communications they have created mouse models of both papillary and clear cell renal cell carcinoma that faithfully mimic the genetic changes seen in tumors of patients with these cancers.

Promising results found for treatment of melanoma in the brain
UNC Lineberger Comprehensive Cancer Center

At the American Society of Clinical Oncology Annual Meeting 2017 in Chicago, researchers presented promising data for two different investigational drug regimens used to treat melanoma that has spread to the brain, a common and deadly complication of this cancer.

Black, white men view impacts of prostate cancer treatment differently, study finds
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Ronald C. Chen surveyed 1,171 men diagnosed with prostate cancer in North Carolina, finding that while both white and black men were concerned about curing their cancer and the quality-of-life impacts of treatment, more black men considered other social and personal factors -- such as recovery time and cost -- to be very important in their treatment decision-making.

Cancer patients who systematically reported their symptoms lived longer
UNC Lineberger Comprehensive Cancer Center

A study presented at the American Society of Clinical Oncology is the first to find a survival benefit for patient reported outcomes.

With ‘new life’ after transplant, cancer survivor renews marriage vows
UNC Lineberger Comprehensive Cancer Center

Recognizing that her husband now had a chance for a new, healthier life thanks to a stem cell transplant, Jackie Hannah secretly arranged for a ceremony for her husband David and her to renew their marriage vows. While he was in the Bone Marrow Transplant Unit in March, just after the transplant, and still dressed in his pajamas, David married Jackie again with hospital staff in attendance.

Researchers continue to seek strategy for starving brain tumors
UNC Lineberger Comprehensive Cancer Center

In the journal Cancer Research, UNC Lineberger researchers led by member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify a suitable therapeutic target within the sugar metabolism pathway, and provide clues to a scientific mystery surrounding the confounding way that some cancer cells get energy from sugar.

Symposium outlines career options for postdoctoral fellows
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger invited postdoctoral fellows to hear from three scientists who have chosen different science career paths after earning their doctoral degree.

Payments linked to higher odds of doctors prescribing certain cancer drugs
UNC Lineberger Comprehensive Cancer Center

In preliminary findings that will be presented at the American Society of Clinical Oncology Annual Meeting 2017 in Chicago on Saturday, June 3, researchers show that when physicians had to choose between multiple, on-patent drugs for metastatic kidney cancer and chronic myeloid leukemia, they were more likely to prescribe drugs from companies they had received general payments from.

UNC Lineberger’s symposium facilitates new ideas, collaborations
UNC Lineberger Comprehensive Cancer Center

Fifteen speakers shared their latest research at UNC Lineberger’s 41st Annual Scientific Symposium, which was held at the William & Ida Friday Center for Continuing Education on the theme of “Developmental Signal Transduction Pathways in Cancer.”

UNC-Chapel Hill spinout company generates more than $108M in stock offering
UNC Lineberger Comprehensive Cancer Center

Founded with support from KickStart Venture Services, a UNC-Chapel Hill program that works to turn University research into new companies, G1 Therapeutics is developing novel therapeutics based on discoveries at UNC Lineberger Comprehensive Cancer Center.

UNC Lineberger physicians, researchers to share study findings, clinical expertise at ASCO Annual Meeting 2017
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger physicians and researchers will present their study findings at the 2017 American Society of Clinical Oncology Annual Meeting, which is expected to draw thousands of people to Chicago this weekend.

Superior Court Judge Carl Fox to speak at UNC Cancer Survivors Day on June 10
UNC Lineberger Comprehensive Cancer Center

The annual day celebrating cancer survivors and their caregivers will include interactive educational talks and discussions and is free and open to the public.

Strategy significantly boosts colorectal screening
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Dan Reuland, MD, MPH, report in the Journal of the American Medical Association Internal Medicine that providing one-on-one support and customized tools for decision-making increased screening rates for patients at two community health centers in North Carolina and New Mexico.

UNC Lineberger marks Clinical Trials Day
UNC Lineberger Comprehensive Cancer Center

Clinical Trials Day honors clinical research professionals by recognizing their contributions to public health and medical progress. UNC Lineberger faculty and staff celebrated the day by sharing photos on social media.

UNC Lineberger’s 41st Annual Scientific Symposium to focus on signal transduction in cancer
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's 41st Annual Scientific Symposium will focus on "Developmental Signal Transduction Pathways in Cancer.” The symposium will be held May 22-23 at the William and Ida Friday Center for Continuing Education in Chapel Hill.

Strategy significantly boosts colorectal screening for groups with low rates
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers led by Dan Reuland, MD, MPH report in the Journal of the American Medical Association Internal Medicine that providing one-on-one support and customized tools for decision-making increased screening rates for patients at two community health centers in North Carolina and New Mexico.

UNC Lineberger celebrates Nurses Week
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger marked National Nurses Week by highlighting three N.C. Cancer Hospital nurses who take such incredible care of our patients.

In ovarian cancer, researchers uncover new drivers of cell division
UNC Lineberger Comprehensive Cancer Center

In a study published in the journal Molecular and Cellular Biology, UNC Lineberger researchers report that they’ve discovered a key activator that can turn on FoxM1, a protein that drives expression of genes that help cells replicate and divide. They also discovered, paradoxically, that the activator for FoxM1 is also responsible for turning this protein off.

UNC Lineberger team helps make Pancreatic Cancer Purple Stride 5K a success
UNC Lineberger Comprehensive Cancer Center

UNC's Running RAScals participated in this year’s PanCAN #PurpleStride run on Saturday, April 29th. The team, organized by Kirsten Bryant, PhD, consisted of 76 members and raised over $13,000 to support the Pancreatic Cancer Action Network.

Finding genetic variations common in black women could improve breast cancer outcomes, reduce recurrence
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers Charles M. Perou, Katherine Hoadley and Melissa Troester co-authored a large, multi-institutional study designed to understand a gap in mortality for black and white women with breast cancer by beginning to unravel the germline genetic variations and tumor biological differences. This is the first “ancestry-based comprehensive analysis of multiple platforms of genomic and proteomic data of its kind,” the authors note.

Robert McGinty named 2017 Searle Scholar
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Robert McGinty, MD, PhD, has been selected as a 2017 Searle Scholar. He is the first Searle Scholar named at the University of North Carolina in the past 10 years.

Researchers map genetic changes in glioblastoma as it progresses, test potential treatment strategy
UNC Lineberger Comprehensive Cancer Center

In a pair of preclinical studies published in the journal Neuro-Oncology, researchers from UNC Lineberger and the Phoenix-based Translational Genomics Research Institute report on the genetic evolution of glioblastoma as it progresses in severity and a potential strategy to treat this often fast-growing brain cancer type.

Study confirms link between alcohol consumption, breast cancer risk in black women
UNC Lineberger Comprehensive Cancer Center

In findings published in the journal Cancer, Epidemiology, Biomarkers & Prevention, UNC Lineberger Comprehensive Cancer Center researchers confirmed the link between alcohol consumption and breast cancer risk in a study in black women. The association has been seen in other studies drawn from majority white populations.

Images of health risks make indoor tanning messages more effective
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers report in a new study that anti-tanning bed messages with images showing longer-term health effects, such as skin cancer or wrinkles, produced greater negative emotional reactions and higher ratings of effectiveness in a survey of female college students than text-only messages.

UNC Lineberger researchers speak at governor's mansion for launch of Metastatic Breast Cancer Awareness Month
UNC Lineberger Comprehensive Cancer Center

N.C. Gov. Roy Cooper declared April as Metastatic Breast Cancer Awareness Month in North Carolina to bring attention to this second-leading cause of cancer death among women. UNC Lineberger researchers joined First Lady Kristin Cooper at the Executive Mansion on Monday at a luncheon hosted by the North Carolina Oncology Navigator Association.

Lineberger researchers speak at governor's mansion for Metastatic Breast Cancer Awareness Month
UNC Lineberger Comprehensive Cancer Center

N.C. Gov. Roy Cooper declared April as Metastatic Breast Cancer Awareness Month in North Carolina to bring attention to this second-leading cause of cancer death among women. UNC Lineberger researchers joined First Lady Kristin Cooper at the Executive Mansion on Monday at a luncheon hosted by the North Carolina Oncology Navigator Association.

UNC Lineberger receives $4 million gift to support promising new cancer treatment
UNC Lineberger Comprehensive Cancer Center

Seeking to help in the development of treatments for metastatic cancer, Alice Lehman of Charlotte has donated $4 million to further the work of UNC Lineberger's new cellular immunotherapy research program.

Cancer burden for aging U.S. HIV population projected to shift
UNC Lineberger

UNC-Chapel Hill researcher Jessica Y. Islam, in collaboration with the National Cancer Institute and Centers for Disease Control and Prevention, reported findings Wednesday at the American Association for Cancer Research Annual Meeting that the total number of HIV-positive cancer patients in the United States is projected to decrease through 2030. She and her collaborators also projected that there would be a decrease in cancers linked to the advanced stage of HIV infection -- AIDS.

Lineberger researchers speak at N.C. Executive Mansion for Metastatic Breast Cancer Awareness Month proclamation
UNC Lineberger

N.C. Gov. Roy Cooper declared April as Metastatic Breast Cancer Awareness Month in North Carolina to bring attention to this second-leading cause of cancer death among women. UNC Lineberger researchers joined First Lady Kristin Cooper at the Executive Mansion on Monday at a luncheon hosted by the North Carolina Oncology Navigator Association.

Nanoparticle treatment could improve immunotherapy against cancer
UNC Lineberger

In preliminary findings that will be presented Sunday, April 2, at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger researchers report on a preclinical study into the use of nanoparticles to improve the efficacy of immunotherapy drugs known as checkpoint inhibitors.

Aggressive breast cancer grows faster in obese environment
UNC Lineberger

In an abstract that will be presented at a poster session to be held from 1 to 5 p.m. April 3 at the American Association for Cancer Research Annual Meeting 2017, UNC Lineberger researchers will report their preliminary findings that breast cancer cancer cells grew larger when they were transplanted into fatty, obese tissue.

Broad support exists for larger warnings on cigarette packs
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger researcher Adam Goldstein, MD, MPH, and Sarah Kowitt, MPH, found broad support, even among smokers, for increasing the size of health warnings on cigarette packs.

UNC Lineberger researchers to present at AACR Annual Meeting
UNC Lineberger Comprehensive Cancer Center

The 2017 American Association for Cancer Research Annual Meeting meeting in Washington, D.C., April 1-5, is expected to draw more than 20,000 scientists, clinicians, advocates, and others, including UNC Lineberger faculty, to discuss advances in the field of cancer science.

Preterm births more common in mothers who are cancer survivors
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger's Hazel Nichols, PhD, Chelsea Anderson, MPH, and their colleagues report that women diagnosed and treated for cancer during their childbearing years more commonly gave birth prematurely, and to babies whose weights were below normal. Cancer survivors also had a slightly higher rate of cesarean section deliveries.

UNC Lineberger expands cancer survivors’ program to more N.C. locations
UNC Lineberger Comprehensive Cancer Center

Through the N.C. Cancer Survivorship Provider Action Network (NC-CSPAN), cancer survivors and their loved ones can participate in a free, four-week educational program on nutrition, exercise, coping with stress and medical care. The program seeks to engage survivors to smooth the transition from active treatment.

Society for Gynecologic Oncology annual meeting features UNC Lineberger data, honors two researchers
UNC Lineberger Comprehensive Cancer Center

The Society for Gynecologic Oncology’s 2017 Annual Meeting for Women’s Cancerwas held March 12-15 in National Harbor, Maryland.

New insights into side effects can help prostate cancer patients choose treatments
UNC Lineberger Comprehensive Cancer Center

In the Journal of the American Medical Association, a study led by UNC Lineberger member Ronald C. Chen, MD, examines quality-of-life outcomes for modern treatment choices most patients will face, including active surveillance, radical prostatectomy, external beam radiation treatment, and brachytherapy.

ASPO honors Ribisl with Joseph W. Cullen Memorial Award
UNC Lineberger Comprehensive Cancer Center

Ribisl recognized for his research evaluating and improving the reach of population-level efforts to reduce tobacco use with a particular emphasis on policy and information technology.

Earp, Ting recognized for career achievements in cancer research
UNC Lineberger Comprehensive Cancer Center

H. Shelton Earp, MD, director of UNC Cancer Care and the Lineberger Professor of Cancer Research, and Jenny P.Y. Ting, PhD, UNC Lineberger member and William Rand Kenan Professor of Genetics, have been honored with the Hyman L. Battle Distinguished Cancer Research Award.

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases
UNC Lineberger Comprehensive Cancer Center

In a study published in journal Nature Immunology, researchers led by UNC Lineberger member Jenny P.Y. Ting, PhD, describe how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the balance of bacteria living in the gut. Beneficial bacterial may be the key to reversing inflammation in the absence of this key regulator.

Spring deadline is March 15 for cancer research grant proposals
UNC Lineberger Comprehensive Cancer Center

There are two categories of awards offered this spring for the UNC Lineberger Developmental Funding Award: Pilot Awards of up to $50,000 for one-year projects involving one principal investigator, and Stimulus Awards of up to $100,000 per year for one or two years for projects that enhance our scientific understanding of cancer basic mechanisms or clinical and public health practice.

Patients and their records agree on medical history for most maladies
UNC Lineberger Comprehensive Cancer Center

A study led by UNC Lineberger researcher Ronald Chen, MD, found that a group of prostate cancer patients reliably reported their own medical histories when their responses were compared to their medical records.

Researchers awarded grant to study strategy to improve immunotherapy response
UNC Lineberger Comprehensive Cancer Center

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

Measuring patients' muscles to predict chemotherapy side effects
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger researchers Hy Muss, MD, Shlomit Strulov Shachar, MD, and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for side effects that could require hospitalization.

UNC Lineberger launches innovative cellular immunotherapy program
UNC Lineberger Comprehensive Cancer Center

UNC Lineberger, with its U.S. FDA-approved Good Manufacturing Practices, or “clean,” facility, is one of only a select academic centers in the United States with the capability to genetically modify patient immune cells for clinical use. This makes it possible for people who live in the Southeastern U.S. to stay closer to home to undergo cellular immunotherapy treatment.